This suggests that the role of H3K79me2/3 is very gene and context specific and underscores the importance of future work designed to further explore the function of this important histone mark and the complexes that regulate it.
This study was designed to further explore the importance of exogenous tPA in revealing PCI activity in rat models of venous and arterial thrombosis and provoked bleeding.
Thus, it should be interesting to further explore the importance of both NAD-dependent and -independent HDACs in telomeric silencing.
In order to further explore the importance of known and new polymorphisms in female reproductive function, it is essential that studies are well-designed and sufficiently powered.
To further explore the importance of the beta-1 class of integrin receptors and ILK in mammary tumorigenesis, we have generated mammary-specific knockouts of either beta-1 integrin or ILK using the Cre/LOXP recombination approach.
Since Tbdn forms a complex with Cortactin (Paradis et al., 2008), we used a Cortactin siRNA (Schnoor et al., 2011) to further explore the importance of Cortactin on Albumin permeability and Src family of kinases activation in the context of suppressed Tbdn expression in retinal endothelial cells (Fig. 4).
To further explore the relative importance of histone lysine acetylations, we classified the group I exon intron junctions against the distal constitutive ones and obtained a comparable classification accuracy as using all 24 modifications.
To further explore the functional importance of the small, but consistent Conk-S1-induced decrease in Kv currents, Rb+ effluxes through KATP and Kv channels were measured at different concentrations of Conk-S1 in competent, isolated rat islets.
To further explore the relative importance of the landscape in shaping the spatial distribution of genetic structure, we assessed the effect of linear geographic distance and that of the Richelieu River.
Our findings also show the importance of de novo assembly of transcriptome, which could help us to further explore the missing sequences beyond the reference genome.
