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In the last few years it also become clear that – despite their fundamental importance – the expression of many components of the stem cell self-renewal circuitry, including NANOG, is heterogeneous in a population of undifferentiated stem cells [ 7, 9, 11].
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Rockwell has stated that he feels hands are second only to heads in importance to the expression of a story.
The importance of the expression of this protein was also suggested by its upregulation in T3.70+ thymocytes from Rec-HY male mice (Figure 3D).
A set of small nucleoid associated proteins, termed NAPs, has recently been shown to be of major importance for the expression of many growth phase-related genes [37].
A central issue in this context is to identify transcription factors, or transcription factor binding sites, likely to be of importance for the expression of the gene signatures.
Further evidence as to the importance of the expression of key proteins in the Bcl-2 family comes from a prospective, randomized, radiation dose escalation trial that treated 305 men with localized prostate cancer with either 70 or 78 Gy.
However, the selection of the target antigen is of critical importance since the expression of the target antigen on normal tissues could result in toxicity (discussed below).
At the present time, the difficulty is to conclude on the order of importance of the expression of each protein implication in the same way (i.e. cellular proliferation or apoptosis).
In monocytes, it is NFκB1, and not HIF-1α, which is of central importance for the expression of hypoxia-adjusted genes.
In monocytes, it is NFkB1, and not HIF-1α, that is of central importance for the expression of hypoxia-adjusted genes.
This demonstrates the importance of considering the expression of other components of the BER pathway when evaluating the impact of XRCC1 polymorphisms on cancer risk.
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