Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling and cytoskeletal organization.
Despite its importance, supported by findings reported in the literature of extreme outcomes for patients with mCRC treated with chemotherapy, no objective tool allows clinicians to base treatment decisions on this factor.
Better knowledge of EBM did not increase the awareness of its importance, supported by the systematic review of Coomarasamy et al [ 10]. 18.1% became familiar with EBM during their basic training, all of them except one are older than 34 years while the EBM course was only recently integrated in the basic curriculum.
Their importance is supported by the increasing percentage of approved new drug entities that are, in fact, prodrugs.
The topics which were acknowledged by multiple interviewees or whose importance was supported by complementary data are reported in the results section.
This finding provides importance evidence, supported by data from other in vivo and in vitro experimental systems [10] [11], [16] [17], that fluorescent proteins expressed in cells/tissues can modify their molecular composition and cellular activities.
In contrast, internal consistency was good for Kidney-Essence deficiency and Kidney-Qi deficiency which are important domains of KDS-Yin and KDS-Yang, respectively [ 1, 2, 16]; and their importance was supported by that these two domains individually accounted for about 25% of the variance in the EFA data set and that of other domains was less than 10%.
Internal consistency was also good for deficiency heat and deficiency cold which are most important for differential diagnosis of KDS-Yin and KDS-Yang [ 1, 2, 16]; and their importance was supported by a discriminant analysis studying the symptom characteristics of KDS-Yin and KDS-Yang [ 28].
Its importance is supported by observations that the group with relatively and absolutely shortest necks, the Dicraeosauridae and Rebbachisauridae were significantly smaller than all other sauropod groups (Upchurch et al., 2004; Sereno et al., 2007), i.e. that neck length scales with positive interspecific allometry (Parrish, 2006).
Although these increases in AER are small in magnitude, their clinical importance is supported by data showing that AER in what has been considered the "normal range" (<30 mg/24 h) confers independent and significant risk for cardiovascular events and/or death in multiple studies including population-based (8) and cardiac disease (9) cohorts.
It is obviously impossible to examine in detail functions and potential pathophysiological roles of all of the identified alterations, therefore our discussion will focus on selected genes whose expression was found markedly altered and whose potential importance is supported by the existing literature.
