Sentence examples for importance of variants from inspiring English sources

Similarly, the importance of variants with frequencies below 5% may have been underestimated because of inadequate power.

A stepwise logistic-regression procedure was used to evaluate the relative importance of variants within and between the two candidate gene loci.

A stepwise conditional logistic-regression procedure was used to evaluate the relative importance of variants within and between candidate gene loci, as before.

In order to determine the relative importance of variants in terms of phenotypic effect, prediction algorithms were extensively utilized to identify functional amino acid substitutions, and we incorporated results from these prediction algorithms into association tests.

10 The importance of variants linked to this gene was first identified in a genome wide association study (GWAS) when a group of single nucleotide polymorphisms (SNP) identified at specific sites within a haplotype block were found to strongly correlate with either persistence or clearance of HCV in patients receiving interferon treatment.

In this data set, we also tested SAMtools pileup's (Li et al., 2009) performance in order to mark the upper limit of sensitivity and to demonstrate the importance of variant significance testing.

Kwee et al. (2008) and Wu et al. (2010) use where f s is the MAF of the variant, up-weighting the importance of rare variants.

To further delineate the importance of K8/K18 variants in specific human liver disorders, we studied the impact of these variants on overall and liver-related mortality as well as on development of hepatocellular carcinoma (HCC) in a prospectively monitored cohort of French patients with alcohol-related liver cirrhosis.

Our results support the validity of the computational framework to detect novel variants relevant to disease susceptibility studies and provide evidence of the importance of genetic variants in regulatory network studies.

Although functionally uncharacterized, because of the importance of H2A variants to double-strand break repair in other systems, it is hypothesized that these novel variants may have evolved to aid the bdelloids in DNA repair following bouts of desiccation, which the rotifers can survive at any life stage.

Our results clearly suggest the importance of including variants found in the non-coding genome and that prioritization should not just be limited to variants found within protein coding regions.