Sentence examples for importance of variant from inspiring English sources

In this data set, we also tested SAMtools pileup's (Li et al., 2009) performance in order to mark the upper limit of sensitivity and to demonstrate the importance of variant significance testing.

Similarly, the importance of variants with frequencies below 5% may have been underestimated because of inadequate power.

A stepwise logistic-regression procedure was used to evaluate the relative importance of variants within and between the two candidate gene loci.

A stepwise conditional logistic-regression procedure was used to evaluate the relative importance of variants within and between candidate gene loci, as before.

In order to determine the relative importance of variants in terms of phenotypic effect, prediction algorithms were extensively utilized to identify functional amino acid substitutions, and we incorporated results from these prediction algorithms into association tests.

10 The importance of variants linked to this gene was first identified in a genome wide association study (GWAS) when a group of single nucleotide polymorphisms (SNP) identified at specific sites within a haplotype block were found to strongly correlate with either persistence or clearance of HCV in patients receiving interferon treatment.

After detection of significant association, estimates of penetrance and allele-frequency parameters for the associated variant indicate the importance of that variant and facilitate the planning of replication studies.

The recent update of the BIC includes the assessment of the clinical importance of each variant.

Several human association studies support the biological importance of this variant.

Taken together, these findings point out the importance of integrin variant expression in colon cancer cell biology.

In the present study we analyse the importance of the variant among breast cancer patients with a known familial disposition compared to sporadic cases and controls.