These drastic modifications might require conditions that have not yet been found, but that should be explored further given the importance of this interaction in the functionality of the two proteins.
The importance of this sequence in the functionality of the enzyme is strongly suggested by the fact that several other mutations affecting the Exo3 domain have been reported in AGS patients, both in homozygous and in heterozygous form.
A growing body of evidence suggests that under certain pathological conditions, HDL function might be impaired, evidencing the importance of HDL functionality [6,7].
This, for the first time, supports the functional importance of these sites, although the nature of this functionality has yet to be deciphered (Graur et al. 2013).
While many studies have been conducted on HIV and functional limitations, there are very few that examined HIV and early abuse and its combined impact on functionality, highlighting the importance of this study.
Encouragingly, immunization with a ClfA-containing vaccine does induce high titers of such functional antibody, illustrating the critical importance of demonstrating the functionality of antibodies generated during vaccine development.
Despite the slight structural differences between GCN5 and PCAF, we believe that our results extend the importance of this residue as a substrate reader required for crosstalk functionality.
Our data underline the importance of testing the functionality of TIL right after tumor resection, as the functional state of TIL monitored 12 h later is already different from that of freshly isolated TIL and thus, from TIL in vivo.
This chapter focuses on the importance of chemical functionalities on the surface of engineered nanomaterials (ENMs) for environmental applications.
Handy highlights the importance of functionality, much appreciated in Germany.
Compounds with free phenol hydroxyl group showed higher activity compared to methylated derivatives (or counterparts), which confirms the importance of phenol hydroxyl functionality in the interaction with gelatinase.
