Conversely, large-scale interspecific comparative gene regulation studies in the context of development are lacking, despite a growing body of speculation about the importance of divergence in regulatory networks in determining broad evolutionary patterns [ 3, 4].
Matrix metalloproteinase (MMP) expression by tumor cells and surrounding stromal cell types is thought to contribute to tumor progression, although the relative importance of fibroblast-derived proteases remains the subject of speculation.
Speculation regarding the importance of changes in gene regulation in determining major phylogenetic patterns continues to accrue, despite a lack of broad-scale comparative studies examining how patterns of gene expression vary during development.
These studies provoked considerable speculation about the importance of HIF-2α in hypertrophy and OA [ 17], but other studies have raised questions about its role in these processes [ 5, 7].
Cissé underlined the importance of scoring twice with speculation rife: "It is clear scoring two goals in the Super Cup is important for me, because there has been a lot of speculation about me of late and about my position within the club".
The importance of the tongue in modifying the tooth-wear process has long been the subject of speculation.
I have for instance entirely left out his speculations on the importance of music in the process, although they are also relevant to language acquisition, as anyone who talks to toddlers will tell you.
These speculations underscore the importance of identifying barriers that might deter overweight and obese women from obtaining screenings.
Maintaining an equal importance with speculation—Haggadic, philosophic, mystical, or ethical was Halakhah (Oral Law), the paradigmatic statement of the individual and communal behaviour that embodied the beliefs conceptualized in speculation.
Speculation on the overall importance of these genes is limited by the sample size, and the findings merit follow-up.
