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These studies emphasise the important contribution of subtelomeres to phenotypic variation [67] and underscore the importance of sequencing strategies to complete the yeast gene repertoire [14,65].
The growing importance of sequencing in medical care is what motivated Roche to make its current $5.7 billion hostile bid to acquire Illumina.
The high frequency of novel genetic variants shows the importance of sequencing the whole CYP21A2 gene before it can be considered as wild-type.
The importance of sequencing CMV genomes from original fluids stems from knowledge in CMV biology that clinical isolates undergo genetic changes and selection during passage in cell culture [23], and that initial load may determine growth rate.
This finding highlights the importance of sequencing the viral genome directly from clinical specimens.
This finding reinforces the importance of sequencing a large number of individuals belonging to a lineage for describing a detailed phylogeny.
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In both experiments, complete loss of activity demonstrates the importance of sequence context in determining whether substitutions are functionally acceptable.
Besides, the association probability and the sequence load loss obtained from related failures can help to identify the importance of sequences.
Third, given the importance of sequence training for speech tasks, we introduce a strategy to use ReLU+dropout during Hessian-free sequence training of CNNs.
These data suggest that the Notch ankyrin domain folds according to a discrete kinetic pathway despite structural redundancy in the native state and highlight the importance of sequence-specific interactions in controlling pathway selection.
We present evidence for clustering of these recombination events within the population and along the vlsE gene, a role for the direct repeats flanking the variable region in vlsE, and the importance of sequence homology in determining the location of recombination, despite RecA's dispensability.
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