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This does not appear to be borne out by the Precambrian record studied here; instead, a hierarchical order of cycles based on relative importance of sequences allied to a more flexible approach to controls on stratigraphic cyclicity at first- and second-orders is preferred.
Besides, the association probability and the sequence load loss obtained from related failures can help to identify the importance of sequences.
These data also provide support for the importance of sequences upstream of the PDZ binding domain in dictating target PDZ domains and subsequent activity.
In retrospect, what these early experiments may have been demonstrating was the importance of sequences preceding RRM1 in influencing the ability of SR proteins to be recruited to pre-mRNA.
In addition, the same sequence criteria inferred from previous studies for the recognition of mRNA targets by miRNAs [30], [31], [48] [50], especially the importance of sequences complementary to positions 1 8 in the miRNA, emerged independently from analysis of the mRNAs overrepresented in FLAG-Ago2 IPs.
The potential importance of sequences outside coding regions cannot be overemphasized when designing synthetic stand-alone genetic elements.
Similar(51)
These studies emphasise the important contribution of subtelomeres to phenotypic variation [67] and underscore the importance of sequencing strategies to complete the yeast gene repertoire [14,65].
The growing importance of sequencing in medical care is what motivated Roche to make its current $5.7 billion hostile bid to acquire Illumina.
In both experiments, complete loss of activity demonstrates the importance of sequence context in determining whether substitutions are functionally acceptable.
Third, given the importance of sequence training for speech tasks, we introduce a strategy to use ReLU+dropout during Hessian-free sequence training of CNNs.
These data suggest that the Notch ankyrin domain folds according to a discrete kinetic pathway despite structural redundancy in the native state and highlight the importance of sequence-specific interactions in controlling pathway selection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com