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The importance of sequence variation in VAR2CSA as a critical challenge for vaccine development is highlighted.
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Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation.
Although these genes have been well studied because of their medical importance, we demonstrate that a large amount of sequence variation has not yet been described.
We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression.
and approximate size of sequence variation.
Examination of the functional importance of this sequence variation however revealed that there was no negative impact on the activity of the AR 5'UTR in MCF7 or T47D cells.
ACMG recommendations for standards for interpretation and reporting of sequence variations: revisions 2007.
Several papers have called attention to the issue of size homoplasy and the importance of examining underlying sequence variation, but it is not clear that these warnings have been realized among published studies.
These two observations combined point to the importance of identifying VAR2CSA sequence variation, which facilitate parasitic evasion or subversion of host immune response.
Although microRNA research is a relatively young subject, a significant number of studies show the importance of microRNA-related sequence variations in the pathogenesis and susceptibility to particular malignancies.
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