Though R0 resection is oncologically desirable and has been shown to be associated with better survival in several studies, the importance of R0 resection (vs. R1 resection) has been debated recently.
Unlike in patients with R0 resection, there were no significant differences in survival based on LN involvement and relatively modest (though statistically significant) difference in survival based on tumor size in patients with R1 resection emphasizing the importance of R0 resection.
These data emphasize the importance of R0 resection, though the benefit of R0 resection was not uniform and largely confined to a subset of patients with favorable tumor size and LN status.
These findings underscore the importance of R0 resection and careful patient selection for upfront surgery in patients with PaCa.
However, considering the importance of surgical resection of the primary tumour, we decided to use this as a stratification factor for patients in this study.
For the management of the noninvasive bladder cancer EAU, FICBT, NCCN, and AUA guidelines agree about the importance of endoscopic resection in all patients and the benefit of adjuvant intravesical therapy [ 17].
In conclusion, this study reaffirms the importance of completeness of resection and the importance of lymph node involvement in resection for oral carcinoma.
Though the importance of a R0 resection is generally accepted, not all margins are easily managed.
The previously known importance of gross total resection was confirmed by this analysis.
In many studies with fewer patients the importance of a radical resection was already reported.
