Sentence examples for importance of repression from inspiring English sources

Our findings also disclose the importance of repression of TCF/Lef1 activity within the diverse stem and progenitor compartments located above the bulge to support SG lineage commitment.

Third, our study reveals the importance of active repression of alternate fates in lineage-fated cells.

In conclusion, this study unveils the importance of transcriptional repression by a single tissue-specific regulator in multi-lineage primed cells and over tightly defined developmental windows during which lineage-specific gene expression programmes are initiated.

In both cases, the error seems to arise from an over-estimation of the importance of Mig2 repression.

The functional importance of this repression outside the diencephalon is currently unclear; we show here that inhibition of Shh signaling in Pax6 −/− cortex does not prevent abnormal cortical patterning.

To further study the importance of Notch1 repression by miR-34a, expression of miR-34a and Notch1 was examined in 45 breast cancer specimens and 16 normal adjacent breast tissues (NATs).

Moreover, the importance of active repression of ARF to maintain stem cell function (Molofsky et al., 2005), and of ARF reduction to facilitate dedifferentiation (Pajcini et al., 2010) have been documented.

The importance of p16INK4a repression in angiosarcoma was also evident from canine studies that showed sustained expression of p16INK4a in 100% of benign hemangiomas (a total of ten were examined), and p16INK4a suppression in 82% (32 out of 39) angiosarcomas (Yonemaru et al., 2007).

The importance of the transcriptional repression and DNA binding domains suggests a critical role for NKX2.2-mediated transcriptional repression in the pathogenesis of Ewing's sarcoma.

The importance of activation or repression of cap-mediated translation in mesothelioma is strongly emphasised by the observation that an enforced repression of translation in mesothelioma cells resulted in the near total loss of tumourigenic potential.

Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response.