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This result highlighted the importance of pathway reversibility as an effective design strategy for balancing driving force and intermediate accumulation, thereby achieving a self-regulated control for increased net flux towards product biosynthesis.
Overall, this study demonstrated the importance of pathway balancing in 3-HP production as well as the utility of the synthetic cassette architecture for precise control of bacterial gene expression.
Without utilizing a priori knowledge of the relative importance of pathway components, we have applied in silico computational methods to the EGF-induced MAPK cascade.
Enrichment-score values were also calculated, representing the enrichment importance of pathway IDs.
Recently, an importance of pathway analysis has been emphasized in the study of cancer biomarkers.
Though cross-talk is generally defined as a physical interaction between pathway proteins, genetic studies often point out the importance of pathway cross-talks through transcription.
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Our study highlights the importance of pathway-based multiple gene associations to uncover the nature of genetic variance for quantitative traits and may drive novel progress in molecular breeding.
We next asked the question of how the importance of pathways changed during the evolution of species.
The importance of pathways related to steroids in atherosclerosis is substantiated by a variety of data in our study.
Our results also emphasize the potential therapeutic importance of pathways such as CXCR4 and hedgehog for pancreatic cancer treatment.
The general importance of pathways controlling cell proliferation and cell death for cellular senescence is well established (Mallette & Ferbeyre, 2007).
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CEO of Professional Science Editing for Scientists @ prosciediting.com