The growing evidence for the importance of mixed pathology with Alzheimer's, vascular, and Lewy body pathology as well as TDP-43 mediated hippocampal sclerosis and the possibility of additional undiscovered neuropathologies accounting for cognitive decline among the oldest old requires further study and makes targeted disease-modifying therapies less appealing in this population.
The clinical importance of lumbar pathology identified on magnetic resonance imaging (MRI) remains unclear.
Finally, we highlight the importance of digital pathology based on nuclear morphometric features combined with single-cell genomics for early cancer diagnostics.
These new notions include the increased recognition of the importance of extralesional pathology, of the interplay between inflammation and neurodegenerative changes, pathophysiological heterogeneity and additional immune cell populations contributing to disease.
Indeed, many studies were summarized findings on CVD and risk factors in the aetiology of AD and showed the importance of vascular pathology in AD (Jagust, 2001; de la Torre, 2004; de Bruijn and Ikram, 2014).
[1] The importance of RV pathology and dysfunction has been highlighted in several recent publications in terms of impact on a patient's prognosis and therapeutic management [1, 2, 3, 4].
Recently, more attention has been brought to the importance of comparative pathology and pathogenesis in different animal models [21], [26], yet little information is available regarding the actual location of the bacilli in these pulmonary lesions across animal models.
They stress the importance of MTL pathology as an underlying cause, suggesting a role that is not limited to long-term memory, but affects the way in which events are perceived in the first place.
The importance of AD pathology in DLB is not yet clear.
