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Given the notion that unf promotes MB axonogenesis possibly through regulating neuron subtype identity, its selective involvement in late MB morphogenesis could simply reflect the importance of neuron subtype identity in ensuring diverse subtype-specific axonal morphogenesis.
Despite the importance of neuron electrical activity for influencing appetite and body weight, only a few ion channel subunits have been determined in these cell types and little is known about their regulation by energy deficit state.
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These examples highlight the importance of neurons and neuronal gene function in the regulation of lifespan.
- Recently, the critical importance of neurons in which transcription of various neuronal genes such as c-fos is heightened during the memory encoding period was directly tested.
Dr. Leonard Guarente, a biologist who studies aging at the Massachusetts Institute of Technology, described Dr. Ruvkun's work as "an elegant demonstration that really nails down in a convincing way the primary importance of neurons in regulating life span".
In fact, α-syn propagation was more pronounced in the absence than in the presence of neurodegeneration, underscoring the importance of neuron-to-neuron α-syn transfer between intact, relatively healthy cells.
Moreover, a brilliant cell-type sensitive genetic manipulation of the mouse model of ALS, that underlines the importance of neuron-glia interactions, where astrocytes and microglia are found to be implicated in the rate of progression of familial ALS, reported that the damage in astrocytes determines the timing of microglial activation and infiltration [ 49, 50].
The importance of neurons, and likely also astrocytes, in controlling the microglia level of activation is critical to understanding changes in the microglia phenotype in neurodegenerative disease.
Our comparative analysis of CREB1 expression during aging in the intact ganglia and individual neurons highlight the importance of single neuron study of aging.
The high correlation between female preference and neuronal threshold values of the AN1-neuron (figure 2B) points to the importance of this neuron for mate choice decisions [19].
They express the strength, or in other words, importance of each neuron input.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com