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In vivo studies have demonstrated the functional importance of nerve terminal MORs by inhibiting GIRK signalling, the predominant signalling mechanism of postsynaptic MORs (Vaughan et al., 1997).
Given the known importance of nerve supply for regeneration (Gaete et al., 2012; Thornton, 1970), it is important for the development of biomedical strategies to note that bioelectric stimulation of other tissues can induce a strong repair program.
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How can future disease models and considerations regarding NF2 pathogenesis better emphasize the importance of the nerve microenvironment?
44 In addition, a number of human studies had demonstrated the importance of renal nerve signalling in hypertension prior to the publication of the Symplicity HTN-1 and HTN-2 studies.
In the past 15 years much evidence has accumulated which indicates the paramount importance of sensory nerves in reg ulating functions of the gastrointestinal tract.
The confirmation that pain and sensory/motor symptoms systems were separate concepts in the response patterns is important as it verifies the importance of an ulnar nerve specific measure which goes beyond pain questions to capture these additional more disease-specific symptoms.
The sensory/motor symptoms subscale correlated most strongly with overall physical health status indicating the importance of the ulnar nerve symptom items.
Several studies have reported the importance of evaluating retinal nerve fiber layer (RNFL) thickness to diagnose and monitor patients with glaucoma.
Artificial nerve conduits are proposed as an alternative to repair peripheral nerves injuries; while mechanical properties are of great importance for successful clinical application of nerve conduits.
Although an importance of vasoconstrictor skin sympathetic nerve activity (SNA) in control of cutaneous circulation is widely recognized, the decoding rule that translate dynamic fluctuations of vasoconstrictor skin SNA into skin blood flow is not fully understood.
In mature neurons, a functional crosstalk between the cytoskeletal and membrane trafficking machineries might be of particular importance in nerve terminals to ensure the high speed, efficiency and accuracy of vesicle formation and recycling – important for both synaptic transmission and plasticity [7].
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