Sentence examples for importance of msc from inspiring English sources

Thus, the growing importance of MSC for targeted tissue repair could, in part, rely on CCN-protein function.

The importance of MSC within the bone marrow niche in supporting HSC maintenance is evident as depletion of a specific population of nestin positive MSC resulted in a significant reduction in HSC homing and a concurrent increase in mobilisation.

We showed here that MSC secreted IL-6 is key to the growth of the Skov-3 ovarian tumor model while we showed previously the importance of MSC-secreted EGF to the ERα-positive breast cancer model.

In addition, the importance of MSCs derived from the BM and adipose tissues in the regulation of allergic airway diseases has been addressed.

This observation highlights the rather heterogeneous MSC population and the importance of proper MSC characterization and definition for future studies.

While the importance of homing/engraftment of MSC to the injured liver is assumed to be necessary, recent work in liver fibrosis and other clinical settings such as graft vs. host disease has questioned this premise.

Wnt/β-catenin signaling is also of crucial importance for MSCs osteogensis [ 26].

The importance of ERK for MSC differentiation was demonstrated by using the inhibitor of ERK activation, U0126, which completely suppressed osteogenesis of GH-stimulated MSCs on NSQ50.

Importance of donor age of MSC on engraftment and differentiation into hepatocytes has not been evaluated.

The temporal data presented in this study highlights the importance of considering how MSCs respond to extrinsic mechanical signals in the long term.

Given the paramount importance of autocrine/paracrine signaling in MSC functions, elucidating the composition of the pool of proteins secreted by MSC would enhance our understanding on how these cells affect the environment niche, and support tissue repair, immunomodulation, hematopoietic stem cell self-renew, and tumor growth.