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Our results underscore the importance of marker ascertainment for distinguishing phylogenetic terminal branches from basal nodes when attributing ancestral composition and temporality to either indigenous or exogenous sources.
The importance of marker choice in phylogenetic studies has long been stressed.
Our results demonstrate the importance of marker type when attempting to delineate ESUs that have different adaptations and represent an important evolutionary legacy of a species.
Similar(57)
The importance of markers of tissue perfusion should not be overlooked as patients could potentially be at goal MAP, with reductions in CA doses as a result, but still have tissue hypoperfusion.
In general RF yields only the relative importance of markers that explain the variation present in metabolites, but does not give a significance threshold level to select a subset of associated markers.
Such publication bias would thus lead to the literature being biased towards over-estimating the prognostic importance of markers.
The elucidation of disease mechanism and the functional importance of markers involved may eventually guide us to clinical and therapeutic applications.
The "importance of markers" (i.e., an indicator of how a marker in interaction with other markers will successfully classify an individual) was used to select a set of covarying markers which we subsequently refer to as "important markers" (sensu Chen and Ishwaran 2012), for comparison with the single-locus approach.
We investigated the prognostic value of the serum half-life of human chorionic gonadotrophin (HCG) and alpha-fetoprotein (AFP) during induction chemotherapy and the relative prognostic importance of initial marker concentrations and marker half-life.
As for all high-quality, protocol-driven research, we recommend that the statistical analysis plan of a prognostic marker study should be specified in the study protocol and include details of how the independent prognostic importance of the marker will be ascertained in relation to existing markers of clinical importance.
The study illustrated the importance of combined marker analysis, which uses complementary information from two distinct and analogous markers and in the process, offers accurate and reliable results.
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