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Although these issues are not restricted to antibiotics alone, the importance of formulations deserves specific consideration in this context because these are the most widely prescribed class of medicines in paediatrics.
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The process of world globalization and the coalescence of its markets increased the importance of formulation and implementation of accepted environmental standards.
Unstable formulations of low HLB surfactant (HLB = 10) had a toxic effect on cells at high (1 1) surfactant concentrations, indicating the importance of formulation stability for minimizing toxicity.
These modeling techniques allowed rank-ordering of the relative importance of formulation and process variables, and aided in developing an understanding of the drying unit operation.
Throughout, we emphasize that the importance of formulation and analytical characterization in all aspects of vaccine adjuvant development is often underappreciated.
As the development of topical microbicides advances, the importance of formulation is becoming better appreciated.
The simulated discrepancy in oral drug exposure of Sandimmune and Neoral pre to post-RYGB, where bariatric surgery had the highest effect on the oral bioavailability of Sandimmune, highlights the importance of formulation characteristics and its impact on oral drug bioavailability pre- to post-bariatric surgery.
Even though the above theories look convincing, under in vivo conditions, the relative affinity of lipases towards lipid and surfactant will ultimately decide the degrees of digestion and drug solubilization, indicating the importance of formulation optimization using in vitro digestion experiments.
The numerical model CompFlowC++ is used to examine the relative importance of different formulations of a forward dissolution rate model, within the range of parameters measured from laboratory and field studies, for predicting the mean and uncertainty in dense nonaqueous phase liquids (DNAPL) dissolution times in heterogeneous sandy aquifers.
Given the fatal outcome in this case and the importance of vaccine formulations being appropriately targeted, the medical literature was explored to evaluate pneumococcal disease caused by PS38 in the US and outside the US.
Data on compliance are limited and there is no study with TMZ, but interestingly the main clinical importance of iv formulations could be the treatment of noncompliant patients or patients for whom good adherence could not be expected, such as children or adolescents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com