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The significance of the interactions was presented as gene modules and evaluated according to between-ness centrality reflecting the importance of a module in relation to other modules [ 18- 20].
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Importance or function of a module was further assessed by relating modules to the traits "sex," "tissue type," and "species" using an analysis of variance (ANOVA).
The weight indicates the importance of a gene set to a module, relative to other gene sets in that module.
The importance of a gene in a network module is determined by the strength of the correlation to the ModuleEigene, or module membership (kME) value [ 17].
The robot partner system uses calculation for the importance of each module with respect to the external input, and selects what is to be considered centrally.
Importance of this module is supported by its conservation from insects to humans [38].
Altered vesiculation that accompanies mutations of epsin's amphipathic helix points to the importance of this module in vesicle generation.
The phenotype of the chimerical transgenic plants was similar to the observed in transgenic plants bearing the CTR of the donor protein, revealing the importance of this module inside the whole protein.
Statistical metrics from network analyses, such as a centrality measure, which quantifies the relative importance of a protein in communicating between different modules within a network, have been suggested for identifying nodes (proteins in a network) that have attractive properties as potential drug targets [ 42].
Because our perturbation index definition is highlighting the importance of gatekeeper modules, we also calculated a different measure of the perturbation index which is based on the number of gene hits in checkpoint rather than gatekeeper modules, multiplied by the number of active links, as a control.
The importance of the blue module in both genders and the preservation of the module membership measure k M E b l u e (i) demonstrate the value of using network properties to screen for genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com