Mr. Geithner, gaining some confidence, delivered his remarks in simple sentences using a teleprompter, suggesting the importance of communicating a complex issue both to markets and to taxpayers who are reluctantly financing the bailout.
Notably, TCR engagement has been shown to be indispensable for γδ T cell-mediated cytotoxicity whereas NKG2D played only a co-stimulatory role; thus indicating the importance of TCR MIC A complex formation.
Nevertheless, genetic screens for in vivo fusion defects and fusion assays of isolated organelles emphasize the importance of a more complex lipid composition under physiological conditions.
The importance of a functional complex of huntingtin, myosin VI and optineurin during vesicle fusion at the plasma membrane is supported by the fact that the absence of any of these proteins results in a very similar phenotype: a reduction in the number of vesicle fusion events at the plasma membrane and an accumulation of vesicles beneath the plasma membrane (Bond et al., 2011; and this work).
In this context and of particular importance, the formation of a complex composed of integrin α3β1 and FAP on the cell surface has been demonstrated to be necessary for the formation of functional invadopodia on melanoma cells [ 16].
The model proposes that while measurable effectiveness or superiority in outcomes has obvious importance, the success of a complex intervention must also be understood in relation to the workability and integration of it components in practice.
More recently, new findings highlighted the importance of a multi-protein complex involving MYB proteins with bHLH and WDR partners in the coordination of the transcriptional regulation of flavonoid biosynthetic genes.
Downregulation of either pro11 in ∆Smmob3, or Smmob3 in pro11 mutants by means of RNA interference (RNAi) resulted in synthetic sexual defects, demonstrating for the first time the importance of a putative PRO11/SmMOB3 complex in fruiting body development.
In this paper, we introduce Graph Fourier Transform Centrality (GFT-C), a metric that incorporates local as well as global characteristics of a node, to quantify the importance of a node in a complex network.
