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Their importance is supported by the increasing percentage of approved new drug entities that are, in fact, prodrugs.
Its importance is supported by observations that the group with relatively and absolutely shortest necks, the Dicraeosauridae and Rebbachisauridae were significantly smaller than all other sauropod groups (Upchurch et al., 2004; Sereno et al., 2007), i.e. that neck length scales with positive interspecific allometry (Parrish, 2006).
Although these increases in AER are small in magnitude, their clinical importance is supported by data showing that AER in what has been considered the "normal range" (<30 mg/24 h) confers independent and significant risk for cardiovascular events and/or death in multiple studies including population-based (8) and cardiac disease (9) cohorts.
It is obviously impossible to examine in detail functions and potential pathophysiological roles of all of the identified alterations, therefore our discussion will focus on selected genes whose expression was found markedly altered and whose potential importance is supported by the existing literature.
This region contains an extended helix at the beginning of the α-helical domain and its importance is supported by the identification of several disease-causing mutations (S315F, L316F, L316W, Q324L), which were predicted to destabilize the α-helical segment and disrupt its hydrogen bonding with subdomain A [ 16- 18].
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The topics which were acknowledged by multiple interviewees or whose importance was supported by complementary data are reported in the results section.
In contrast, internal consistency was good for Kidney-Essence deficiency and Kidney-Qi deficiency which are important domains of KDS-Yin and KDS-Yang, respectively [ 1, 2, 16]; and their importance was supported by that these two domains individually accounted for about 25% of the variance in the EFA data set and that of other domains was less than 10%.
Internal consistency was also good for deficiency heat and deficiency cold which are most important for differential diagnosis of KDS-Yin and KDS-Yang [ 1, 2, 16]; and their importance was supported by a discriminant analysis studying the symptom characteristics of KDS-Yin and KDS-Yang [ 28].
We found no such association; instead our data imply that the BMI before pregnancy is of greater importance which is supported by data from a larger study [ 10].
The importance of this is supported by Kalkanis et al. who documented that the morbidity rate was lower at specialized high-volume surgical centres [17].
Cleavage of conserved parasite substrates is mediated by SUB1 in all parasite species examined, and the importance of this is supported by evidence for species-specific co-evolution of protease and substrates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com