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Donor safety is of utmost importance in the setting of hematopoietic stem cell donation.
Liver Regeneration is clinically of major importance in the setting of liver injury, resection or transplantation.
This may be of considerable importance in the setting of dietary information presented for weight management.
This is of extreme importance in the setting of elderly patients suffering from multiple comorbidities and associated risk factors.
This is of particular importance in the setting of acute ischaemic reperfusion injury (IRI), where MPTP opening at the point of reperfusion mediates cardiomyocyte death, and inhibiting MPTP opening at this time prevents cell death (Hausenloy et al., 2003; Hausenloy and Yellon, 2003).
This is consistent with previous reports that HIF-1α can be strongly regulated by the redox environment [ 34– 36], a mechanism that is of particular importance in the setting of ischemic brain injury because of the intrinsic changes in redox status.
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More recent studies, however, have questioned the importance of Treg in the setting of sepsis [ 15, 34].
Considering the difficulties in achieving these numbers in critically ill patients, perhaps it is time for clinicians to fully acknowledge the importance of surrogate endpoints in the setting of a study.
However, the importance of platelet activity in the setting of diabetes was noted in small selected populations, and specialized laboratory techniques were used to measure platelet activity.
Below, two GWAS that serve as compelling exemplars of the importance of studying comorbid diseases in the setting of HIV are described.
STAT3 is considered to be an important target molecule for anticancer therapy, and many researchers have thus far reported the importance of various STAT3 inhibitors in the setting of anticancer therapy [ 56].
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