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According to the Stewart approach, chloride is the key contributor to the SID; thus, different amounts of chloride contained in 0.9% saline and balanced solutions are likely of great importance in the pathogenesis of metabolic acidosis.
Evidence is increasing that, apart from genetic alterations, epigenetic changes are of similar importance in the pathogenesis of CRC.
These shared pathways from both gene expression and GWAS therefore have both biological and genetic support for their importance in the pathogenesis of PD.
Dyslipidemia is a well established proinflammatory agent in large arterial vessel disease[21] and could be of importance in the pathogenesis of microvascular complications of diabetes[22].
The genetic importance in the pathogenesis of type 2 diabetes is indicated by several lines of evidence from studies of both twins and first degree relatives of people with type 2 diabetes [1].
Nevertheless, our finding that the frequency of Tc22 cells was also increased in psoriatic dermis may well be of importance in the pathogenesis of psoriasis, because of the keratinocyte proliferation-promoting activity of this cytokine.
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Thus, the identification of proteins involved in regulating LRRK2 GTPase activity and mediating downstream signalling is of fundamental importance in understanding the pathogenesis of Parkinson's disease.
Given the importance of SP in the pathogenesis of PONV, we hypothesized that SP could be used to identify patients with a high risk of developing PONV induced by general anesthesia.
HSP47 is a collagen-specific molecular chaperone that is essential for the biosynthesis of collagen molecule (Nagata, 1998), and both in vivo and in vitro studies have highlighted the importance of HSP47 in the pathogenesis of various fibrotic diseases.
The importance of TLRs in the pathogenesis of IBD in both people and dogs has been reported in the literature [10], [11], [12], [14], [15], [16].
The importance of Nef in the pathogenesis of HIV-1 was investigated after transmission of the virus from an HIV-1-infected blood donor to six recipients.
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