In addition, a growth-promoting role of EpCAM via Wnt signalling, an important pathway in cancers, might not be of general importance in the development of cancer.
The synod was of decisive importance in the development of the German Confessing Church (Bekennende Kirche).
"This is a case of paramount importance in the development of sound First Amendment and intellectual property law," said Dennis J. Niermann, Jireh's lawyer.
The early years of life are, therefore, of paramount importance in the development of what ultimately becomes adult sexual orientation.
As with treatment of any complex disease, there are many events of importance in the development of effective therapy.
American civil engineer and architect whose technical innovations were of primary importance in the development of the skyscraper.
Xunzi's importance in the development of Confucian philosophy rests on the historical influence of his major work, known today as the Xunzi.
St. Paul's historic importance in the development of the Upper Midwest was as a commercial centre that utilized its strategic location on the Mississippi.
Of central importance in the development of Canadian education was the kind of agreement reached on church-state relations in education during this period.
The relationship has been of fundamental importance in the development of the theory of solutions, although few real solutions behave strictly in accordance with it.
Its importance in the development of mathematics was somewhat like solving the cubic equation a small technical achievement but a large encouragement to solve more difficult problems.
