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Genetic approaches have been of decisive importance in discovery of these factors.
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Benzimidazole is a heterocyclic moiety of immense importance in drug discovery [15].
Lipophilicity is a physicochemical property of crucial importance in drug discovery and drug design.
Experimental screening of large chemical libraries, in spite of their specific role and importance in drug discovery, suffer from the disadvantages of being random, time-consuming and expensive.
In silico approaches to predict absorption, distribution, metabolism and excretion (ADME) of new drug candidates are gaining a relevant importance in drug discovery programmes.
Investigation of cell drug interaction is of great importance in drug discovery but continues to pose significant challenges to develop robust, fast and high-throughput methods for pharmacologically profiling of potential drugs.
For this reason, improvement in the identification of drug-target interactions is of great importance in the discovery of additional applications for drugs already in the market, also called drug repurposing, and in drug safety through the explanation of undesirable adverse effects caused by drugs administration.
The CYP3A subfamily has been studied intensively because of its importance in drug discovery; more than half of the drugs in current use are substrates of CYP3A [11].
Detection and imaging of enzyme activity is of great importance in drug discovery research and medical diagnostics.
ChIP-Seq or similar experiments providing genome-wide epigenetic profiles can be also a support of great importance in motif discovery itself.
The integration of some of the SLiMSuite tools with the Cytoscape network analysis platform is likely to be of potential importance in the discovery of SLiMs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com