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One pathway which has been identified as of potential importance in acquisition of drug resistance to Tamoxifen, is the Wnt signalling pathway [ 6].
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These residual anti-MSP3 IgG3 antibodies may contribute to the maintenance of the asymptomatic profile, pointing to its importance in the acquisition of clinical immunity.
Nevertheless, there is a significant population of CD4 T-cells expressing CXCR4 in the mucosa of the female genital tract, so its importance in the acquisition and development of infection needs to be clarified [ 192].
Since intracellular drug accumulation is the basic requirement for chemotherapy agents to exert their effects, upregulation of ABC transporters is of crucial importance in drug resistance acquisition [ 35].
Previous studies suggested the importance of the ANS in acquisition of symbolic numerical abilities [ 61, 62], while others remarked on the role of the OTS [ 63].
Although susceptibility issues are of great importance in echo-planar acquisitions such fMRI or DTI, particularly for inferior frontal regions such as the orbitofrontal area, they are not a major concern for the structural images (SPGR and MPRAGE) reported here.
Partner communication about HIV sexual risk behaviors represents a key area of epidemiologic and social importance in terms of infection acquisition and potential for tailored interventions.
The use of revegetation techniques which lead to more rainforest-like structural conditions appears to be of over-riding importance in catalysing the rapid acquisition of volant rainforest beetle assemblages in the initial stages of restoration.
The sale of Alaska to the United States in 1867 was outweighed in importance by the acquisition of the Maritime Province from China (1858 and 1860) and the founding of Vladivostok as Russia's far eastern capital (1860), the definitive subjugation of the Caucasus (in the 1860s), and the conquest of central Asia (Khiva, Bokhara, Turkestan) in the 1870s.
Perhaps at the very heart of it all is whether there is the critical mass of enough people to whom altruism and social aims are of primary importance, in a world where consumerism, acquisition and ownership have for so long reigned supreme.
HGTs are known to be of a great importance in virulence or antibiotic resistance acquisition by prokaryotes [8], [11], [12], [13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com