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The first consideration of critical importance for therapy is the way the therapeutic gene is introduced into the retina and how its expression is controlled.
Semi-quantitative parameters (for example SUV) gain increasing importance for therapy response monitoring and for assessing the prognosis of patients.
Therefore, the determination of breast tumour hormone receptor status is of major importance for therapy selection [ 33].
Our finding that the mislocalisation of GIST-associated PDGFRα mutant proteins can be prevented and reversed by the treatment with TKIs could be of importance for therapy.
For example, a single biopsy may not be representative of the genetic composition of the cancer, leading to inappropriate choice of treatment; and if a rare subclone exists, what is its importance for therapy?
SUVs and related quantitative measures, such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG), have gained increasing importance for therapy response monitoring [ 30, 61, 68 ] and for prognostic assessment [ 5, 69 – 71 ].
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7 The analysis of the mutational status of melanoma disease clearly shows that the various clinical manifestations of melanoma also differ in their molecular changes, which subsequently will be of importance for therapies directed against tumors bearing a distinct mutation.
Regulated expression of transgene production and function is of great importance for gene therapy.
Strategies to target cancer stem cells are thus of major importance for cancer therapy.
Identification of cell subsets that demonstrate enhanced resistance to drugs would be of importance for melanoma therapy.
Therefore, investigation of survivin expression in different sarcoma entities may have importance for future therapy options.
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