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Each filter corresponds to a column pattern that has been suggested to indicate importance for specificity.
This suggests that the low-overlap pattern alone is insufficient to indicate importance for specificity; a method that rewards this column pattern is likely to select columns that are far from relevant ligands.
When evaluating SDP predictions in the absence of experimental data, many researchers have used nearness to relevant ligands as a proxy for importance for specificity (see Hannenhalli and Russell, 2000; Kalinina et al., 2003).
If two columns have the same SDP score (according to any method), we might think that the one in the area of greater conservation is likely to be of greater importance for specificity.
Similar(56)
Clones B10 and B13 originate from the same VH chain rearrangement and share the same CDRH3, considered to be of crucial importance for antibody specificity 38.
The regimens described here provide similar neutralization titers, and thus are useful for investigating the importance of specificity in non-neutralizing antibody mediated protection against viral challenge.
What the trash receptacles illustrated to me was the importance of specificity.
This demonstrates the importance of specificity in cancer cell proliferation.
6 7 9 38 This result highlights the importance of specificity of training.
Hence, the structure of the substrate-binding cleft has importance for the substrate specificity and correlates with the endo- or exo-activity of family 18 glycoside hydrolases (Hurtado-Guerrero and van Aalten 2007).
Many positively selected amino acids were found in specific regions known to be of major importance for enzymatic activity and substrate specificity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com