Determining how environmental controls regulate these two metrics of the fire regime is of critical importance for predicting response of fire to climate change and designing strategic fire management plans.
Nevertheless, three-dimensional skin architecture is of fundamental importance for stress response [37], [38] and the expression of p53 expression fails to be a predictive indicator of pathological outcomes of skin in patients [24].
Semi-quantitative parameters (for example SUV) gain increasing importance for therapy response monitoring and for assessing the prognosis of patients.
Using survival as an end point when evaluating molecular factors of importance for clinical response to RT, also has drawbacks.
Thus, changes in the levels of ER co-activators may be of importance for the response to endocrine therapy.
However, one may hypothesise that large tumours may have a different molecular pattern that could be of importance for the response to radiation.
In conclusion, since eradication of tumour cells is the ultimate goal of anticancer therapy, cell death detection is considered of high importance for (early) response assessment.
SUVs and related quantitative measures, such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG), have gained increasing importance for therapy response monitoring [ 30, 61, 68 ] and for prognostic assessment [ 5, 69 – 71 ].
It became clear that the vascular component was of major importance for the response of tumours in mice (Bibby et al, 1989; Hill et al, 1989; Zwi et al, 1989).
Given the relevance of the tissue for drug metabolism, we identified miRNAs significantly correlated with the expression of the so-called Very Important Pharmacogenes (VIP Genes) as maintained by PharmGKB [ 14], comprising a list of genes of particular importance for drug response.
