Interestingly, the statistical analyses support our hypothesis that radial angulation of the wrist is of lesser importance for activity and participation than active wrist and finger motion.
To allow a medicinal chemist to interpret a linear model, it is intuitive to color each atom or bond of a molecule according to its importance for activity.
Based on the weights of a linear model, the visualization approach colors each atom and bond of a compound according to its importance for activity.
MMP-2 localizes at the migrating edge of TLX-expressing TIC clusters in the xenograft sections of human NB-TICs, suggesting its importance for migratory activities of cancer cells, which may result in invasiveness leading to metastasis.
It scales with activity concentration and is of importance for high activity and microfluidic PET tracer synthesis.
Autophosphorylation at the activation segment residue T180 has been suggested to be of functional importance for DAPK3 activity, because a T180A mutant is resistant to activation and suppresses DAPK3 function in cells (Graves et al, 2005).
Additionally, we found that the lipid environment of the V-ATPase is of essential importance for its activity, suggesting a second mode of regulation and highlighting that the V-ATPase activity is modulated by multiple, simultaneously operating, mechanisms.
The catalytic activity increases with decreasing nanoparticle size, due to higher specific surface area [33], but also the shape of particles and especially the active step sites have been shown to be of outmost importance for catalytic activity [36].
Another dissolved gas of prime importance for biological activity is carbon dioxide.
E. coli can use oxygen, nitrate, or nitrite as an electron acceptor, and Pseudomonas stutzeri is of major global importance for its activity in denitrification, the conversion of nitrate to nitrite and dinitrogen gas (N2).
