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The organelle import specificity is mediated by one or more components of the Toc complex.
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For example, one might think that anyone who interprets the English word 'heap' as requiring a pile of n items for any specific n is wrong, since they are trying to import more specificity into the meaning of the word than can really be found there.
She wrote a few more books and began translating Grimms' Fairy Tales, importing her characteristic specificity.
The absence of a rigorous discrimination between export or import pathways and substrate specificity may arise from a rather complex hierarchy of binding affinities.
The presence of a dedicated receptor-ligand (TOM-NTS) pair for recognition and import would allow increased specificity of TOM interactions and thus channel substrates to the TIM complex.
Why is specificity important?
In this model, Importin-α confers cargo specificity to the import machinery [6] and is the necessary intermediary between the cargo and Importin-β.
How is selectivity maintained in such an import system of seemingly low specificity?
Recently, we could show that human mitochondria, in contrast to their fungal counterparts, exhibit a certain specificity regarding the import and assembly of bacterial β-barrel proteins.
This enzyme is a duplicate of the cytosolic GapC that obtained a bipartite signal-/transit-peptide for plastid import and adapted its cosubstrate specificity from NAD+ to NADPH to fulfill its novel function in the anabolic Calvin cycle (Clermont et al. 1993).
But, beside sensitivity and specificity it is also import to know how well the CAD system does perform on datasets from different sites with different slice thicknesses and differences in the dosage.
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