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Our results reveal a previously unappreciated function of the CTD of NFAT5, and indicate that the control of its nucleo-cytoplasmic localization in cycling cells resides not only in import and export sequences located in its amino-terminal region [20], [22].
In addition, MDM2 contains nuclear import and export sequences (Momand et al, 2000).
However, SIRT1 has both nuclear import and export sequences and was found present in the cytosolic fraction of the mouse brain (Tanno et al, 2007).
The presence of ARM domains in combination with nuclear import and export sequences renders p120 capable of shuttling in and out of the nucleus (Kelly et al., 2004b; Roczniak-Ferguson and Reynolds, 2003).
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With one report on PINCH1's nuclear import and export sequence and its nuclear localization [51], PINCH1 might influence such kind of processes via its function as adapter protein and/or via its putative function as transcription factor.
Tus may be the first prokaryotic protein known to carry both nuclear import and nuclear export sequences.
Combined with programs in Stacks that import and export these sequences from the database, it becomes straightforward to perform conserved synteny analyses on genetic maps (see Amores et al. 2011).
Import and export of annotated genomic sequences are provided at the web interface for FASTA, EMBL and GenBank files.
Notably, by using various nuclear import or export sequences fused with VHL, a previous study has indirectly showed that specific subcellular localization affects the antitumor properties of VHL [28].
It provides import and export functions for file formats commonly used for sequencing data: Fastq, Qseq, FASTA, SAM and BAM.
Importins and exportins identify their protein cargoes by nuclear localization sequences (NLSs) and nuclear export signals (NESs), which ensure their nuclear import and export, respectively.
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