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Perhaps a similar approach could be applied to the CLIPB14 and FBN8 proteins and reveal the role of the positively selected sites in the proteins' structures implying function and their possible involvement in the defense against Plasmodium and/or other microbes.
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The best, made around 1935, depict tabletop arrangements of organic forms (recalling Arp and Miró) that resist recognition, but imply function; one biomorphic blip sports a circle inscribed with a dash that looks uncannily like the head of a screw.
Any omissions imply function defaults.
Why then does binding not necessarily imply function?
Although the same "conservation implies function" principle applies in this case, it needs to be used more cautiously.
This is consistent with a previous finding that physical interactions imply function in a single pathway and are orthogonal to synthetic lethal interactions [ 27, 28].
A separate collection of unfertilized eggs was taken to determine the maternal contribution to transcript abundance of selected CYP genes, which could imply function in early development.
Further functional experimental studies will be needed in order to fully verify these as real ncRNAs since transcription does not imply function.
Yet, in vivo and in vitro, binding of transcriptional control (TC) proteins to their cognate DNA response elements (REs) or of protein molecules to their protein partners does not imply function.
We established transcription for several of the nuwts examined, however transcription does not necessarily imply function [ 5] and it appears that low-level transcription is common among nuwts [ 4, 11- 13].
The accumulated ESTs allow researchers to identify tardigrade-specific RNA motifs and tardigrade-specific (M. tardigradum and/or H. dujardini) ESTs as well as ESTs where the implied function occurs in other species, including Homo sapiens.
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