This concomitant increase in HR and BP implies modulation of baroreflex function.
Also GO-terms involved in translation regulation seem to be affected e.g. "regulation of translation" (GO 0006417), "translation regulator activity" (GO 0045182) and "translation factor activity, nucleic acid binding" (GO 0008135), implying modulation of translational activity as a response to desiccation.
The experiments showed the same trends as the simulations, but with slightly lower variability, possibly implying modulation of the noise through metabolism and cell division, leading to the phenotypic response.
We hypothesise that this is because in monkey K, PC1 is near zero during the early phase of the decision, but strongly modulated during the later phase, which might imply a modulation by value difference as opposed to overall value.
This could imply a modulation of biological activity, as observed for cathepsins B and L in the presence of GNP [64] possibly leading to an impairment of the cell machinery, a recognition of immunoglobulins or unfolded protein leading to macrophage activation [55],[65] and inflammation [66].
Taken together, these data imply that modulation of load-induced mitochondrial biogenesis may contribute to the beneficial effects of MEF2C depletion in overloaded myocardium.
Re-distribution and up-regulation of CLC2 expression and an increase in chloride transport imply that modulation of chloride ion transport is an active response to wounding that plays a role in cellular guidance and migration as well as tissue stratification, which occurs later in the wound healing process, after epithelial cells have covered the entire wound bed [29].
Activated movement of smooth muscle cell and migration/movement of endothelial cell may imply phenotypic modulation of those cells.
Taken together, these functional data imply that modulation of FA composition to increase resistance to lipid peroxidation is one of the mechanisms by which IIS mutants extend longevity.
