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The scarcity of theoretical models implies the difficulty of finding realistic theoretical models.
The maximum frequency waveforms extracted from these estimated spectrograms include considerable distortion and illegibility, which implies the difficulty in finding correct indices used for quantification of vascular diseases' severity from the spectrograms.
As shown in Figure 6, the AFM imaging of our sample using a cantilever with a stiffness of 1 N/m leads to the detachment of AuNPs from the surface during the imaging, which implies the difficulty in accurately measuring the friction force between AuNPs and surface (i.e., SA or SD). Figure 5a,b shows the AFM/LFM images of AuNPs attached to SD or SA.
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In addition, the average sequence identity between drug-target pairs sharing the same drugs (i.e. promiscuous drugs) was only 0.0311, showing the diversity of targets in promiscuous drugs and implying the difficulty of clustering drug-target pairs by drug or target information only (Table S8).
Meanwhile, several other pilus pseudo atomic models have been proposed, such as the type IVb toxin-coregulated pilus (TCP) from Vibrio cholerae [ 12] and pseudopili of the pullulanase T2SS (the PulG pili) from Klebsiella oxytoca that consist essentially of the major pseudopilin subunit PulG [ 13], which might also imply the difficulty of acquisition of intact pilus filaments structures.
The unforeseeable nature of the pain and extent of the active pain relief strategies (called coping strategies), developed by patients with SCD, are different from other painful disorders in which similar analgesic treatment is used, and imply the difficulties patients and health care professionals experience in managing it [ 21, 22].
This implies that the difficulty of the task must be taken into consideration when designing tournaments.
Instead, some information about the gene derives from experiments in rodents where AVPR1B function is abolished by either genetic manipulation or antagonist administration; these experiments imply the inherent difficulty in translating mouse phenotypes to humans, which is even more complicated in the case of genes involved in complex behavioral traits, as AVPR1B is suggested to be.
If things had gone wrong, as implied by the difficulty of meeting, then knowing the person in real life would make it harder to get over them.
Or so implies the defense.
So implies the research.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com