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Transcription implies recruitment of RNA polymerase II and transcription factors (TFs) by DNA melting near transcription start site (TSS).
The classical view on dermal wound healing implies recruitment of local fibroblasts [ 104] followed by a subsequent process of transdifferentiation in which the fibroblasts gain a definitive phenotype of differentiated myofibroblasts by neo-expressing a-smooth muscle actin (α-SMA).
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This implies that recruitment of lysosomes by KIF5B to microtubules may localize or queue them and not necessarily facilitate long distance travel.
Current models propose that key components of transcriptional complexes are functionally compartmentalized [35], [36] so that the achievement of a transcriptionally active status implies physical recruitment of chromatin and related proteins.
This implies that recruitment for a long-term study with these elements might be difficult, yet not impossible.
In higher eukaryotes, transcriptional regulation implies the recruitment of a set of regulatory proteins that bind on combinations of nucleotide motifs.
This observation implies the recruitment of members of the leucyl/phenylalanyl-tRNA-protein transferase family to catalyze peptide bond formation within the biosynthesis of natural products.
Oligoclonal expansions of T cells are present in synovial fluid as compared with peripheral blood and these T cells show an activated, highly differentiated memory phenotype that implies selective recruitment from the blood [ 5, 6].
This indicates that H3K4me3 and recombination are not tightly linked and, since H3K4me3 causes the recruitment of RAG2 (Ji et al, 2010b), these data imply that recruitment of RAG2 is not sufficient for full activation of Igκ recombination.
IgA, IgX, and IgT have been suggested to be products of convergent evolution, implying the recruitment of a unique immunoglobulin to mucosal immunity at least three times [39].
Given that PI3K represents a signal transduction event associated with cell activation [28], we considered the possibility that VHCDR3-mediated activation might imply PI3K recruitment.
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