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In other words, domain proximity implies phenotype similarity.
In other words, semantic similarity of genes implies phenotype similarity of diseases that the genes are associated.
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Using these data, we show that domain proximities calculated from a domain-domain interaction network do, indeed, imply phenotype similarities of diseases.
The fact that there is discordance with regards these actual or implied phenotypes in humans and the mouse phenotype described here most probably reflects differences in the nature of the mutations involved.
Using phenotype patterns to generate secondary phenotype predictions implies that phenotypes that co-occur often with each other, are likely to always co-occur.
An individual with all '0' alleles has phenotype 0, which implies all phenotypic values z are scaled relative to that of this genotype.
Estimating epistasis for quantitative categories of phenotypes implies calculating how much the phenotype of a double mutant deviates from an expected additive value based on the effect of the single mutations (Fisher, 1918), therefore requiring accurate measurements of the phenotype of the single and double mutants.
Downregulation of two PRXs in the dxr mutant causing an albino phenotype implies that those genes have roles in processing ROS produced during photosynthesis.
This phenotype implies that gp150 normally covers a cell-binding epitope.
The TRIM3 RNAi phenotype implies that TRIM3 normally functions to suppress the postsynaptic levels of Shank1 protein in neurons.
The population genetics approach examines the footprint of natural selection which implies a selectable phenotype, possibly even a subtle one that cannot be assayed in the lab.
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