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The importance of cellulosic surface exposure to microbial hydrolysis has received little attention despite its implied impact on conversion kinetics.
Moreover, the 3D location of substituted amino acids shed light on the implied impact on the protein's function: An exchange of buried residues may, for example, affect protein stability and folding, whereas mutations located on the protein surface, close to putative binding sites can alter binding affinities.
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We will be increasingly asked to demonstrate that radiology works in favour of patients, not only in terms of diagnostic performance but also at higher levels of the evidence-based medicine hierarchy, which implies impact on treatment, patient outcome, and societal effects [50].
In case of the L860P mutation, homology modelling implied an impact on the channel stability that might result in misfolded Cav1.4 channel protein.
Reduced trucking needs on roads may imply negative impact on the trucking providers, and positive impacts as seen from a different angle: reduced congestion and pollution, more sustainability.
The interface between the realtime simulation model and physical devices is a system theoretic challenge as its design implies significant impact on both stability and accuracy of the real-time control system.
In both cases, oxidation of PTEN results in only small structural changes implying minimal impact on phosphatase-independent functions.
Dicer, Drosha, and miRNAs are involved in cell growth and differentiation, implying an impact on tumorigenesis [ 39].
Caregivers themselves are often aged, and although caregiving implies an impact on daily life that exceeds the boundaries of usual informal care, the impact differs across caregivers.
They are also large relative to what service enrollment would have been in the absence of ticket; the 48-month estimates imply relative impacts on the order of 50percentand25percentcent for the two phases, respectively21.
Here, we provide a novel concept for RCC classification implying potential impacts on tumor diagnostics and the development of tailor-made therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com