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The association of DNase-protection with C LZ troughs implied functional roles for low-complexity regions.
As argued for the SVMPs, the substantial CTL cluster diversity and implied functional diversity would be consistent with the known variation in CTL activity.
Together with the cluster analysis, this strongly implied functional overlap between STAT2/IRF9 and ISGF3 in human and mouse cells, especially for the potential of generating an IFNα-induced antiviral response.
Despite phylogenetic diversity, the implied functional metabolic redundancy observed in the gut metagenomes of individual twins (Turnbaugh et al. 2009a) raises the question as to whether or not important differences exist between the enzymatic capacities of individuals.
For example, several independent rare risk variants with implied functional roles were recently associated with inflammatory bowel disease using next-generation sequencing of pooled samples (Rivas et al., 2011), a design similar to that of Nejentsev et al. (2009) who undertook the first such study and whose data we re-examine here.
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However, our data also suggest a minor role of AtCRT1a and CRT1b for the establishment of full EFR functions (Figure 9; [27]), implying functional interactions between these two types of CRTs in plants.
Accordingly, with improved heart function, animals demonstrate better exercise capacity implying functional improvement.
The reduced expression and altered localization of E-cadherin and other proteins located at cell junctions in the absence of Cav1 imply functional alterations of cell permeability, an important function of MCs during peritoneal dialysis.
This approach has the caveat that sequence homology does not imply functional homology due to possible divergence of gene functions among species.
These major sequence differences between species do not imply functional differences in kinetochore formation, as yeast cenH3 (can4) can functionally replace human CENP-A (Wieland et al. 2004).
In ureteric bud, loss of function of both CFL1 and ADF arrests branching morphogenesis, implying functional redundancy in this context (Kuure et al., 2010).
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