Density for the nicotinamide is diffuse in both protomers, implying disorder, and thus, the nicotinamide was omitted from the final model deposited in the PDB.
It is interesting to note that 50% of the proteins annotated in SWISS-PROT as autoantigens are nuclear proteins but only 21% of human proteins are nuclear, implying disorder may play a role in this enrichment of nuclear proteins as autoantigens.
During the last decade, several prominent theories implied a disordered or weak communication among brain regions as a major deficit underlying ASD etiology and symptoms (Brock et al., 2002; Uhlhaas and Singer, 2006; Geschwind and Levitt, 2007; Kana et al., 2011; Wass, 2011).
These and other sequence characteristics can be used to differentiate between disordered and ordered regions, which in turn implies that disorder is predictable from the sequence.
This is because the theory implies that disorder status/exposure to severe stress may influence the relationship between age and amygdala volumes.
When we stratified method of attempt by co-occurring psychiatric disorder (table 2), hanging and comorbid psychotic disorder implied high rates of suicide (58/69 (84%) during the entire follow-up and 48/69 (70%) within the first year for men; 27/32 (84%) and 22/32 (69%), respectively, for women).
In the same types of analyses, we found that having any Axis II disorder (controlled for Axis I disorders) implied a significantly higher level of mental distress at follow-up.
Although a genetic contribution to severe mental disorders is not disputed, a genetic contribution of perhaps at most 50% implies that disorders cannot be reduced to genetic bases alone.
The law firm, Schillings, said the pictures "gave a seriously false and misleading impression" and implied that the disorder "was so grave and serious that she was wasting away, to the extreme concern of her mother and family".
However, histrionic, depressive, and schizoid personality disorder implied more common among "pure" ADHD subjects (Rydén E, and collaborators, personal communication).
