Furthermore the apparent partial dependence of skin-specific Irga6 expression on IFN action implied by the reduced expression in IFN receptor-deficient mice may suggest that Irga6 expression in the skin is not primarily constitutive but rather due to continuous low-level stimulation of immunity in this barrier site.
Multiple mechanisms are also implied by the normal distribution of the expression ratios Sor55/3153A of Ch5b genes shown in Fig. 1.
In Caenorhabditis elegans, a similiar relationship between the capping enzyme and P-TEFb is implied by the finding that inhibition of expression of the capping enzyme Cel-1 resulted in loss of CTD Ser phosphorylation, without loss of CDK9 expression [ 71].
This conclusion is supported by analyses that involve fitting weighting expressions implied by the Armitage Doll model.
In biology, cluster analysis is implied by the basic assumption that a gene expression profile may have similar features within the group [ 12– 12].
That PS1 regulates PGC-1α expression was first implied by the PGC-1α regulation of many of the PS1-regulated proteins identified by the SILAC/MS/MS screen [e.g., ATP synthase subunits (Wu et al., 1999)].
The correct conclusion should be implied by the Model-2 analysis, where the length effect on the expression levels of TE exons is negative for most samples.
The disparity between these in vitro and in vivo findings could then reflect differences in the homing potential of the three tested MSCs types, as implied by differential expression of integrin-α4 and the inability of integrin-α4-negative BM-MSCs to traffic to the CNS [ 70].
Activation of WNT signalling is further implied by an evident expression of β-catenin within the nucleus rather than in cytoplasm or membrane in tumour-budding cells, as well as increased laminin 5 gamma 2 and activation of SLUG and ZEB1(Muto et al, 2006; Schmalhofer et al, 2009).
The strength of selection on protein sequence implied by expression under these different conditions would vary accordingly.
