Sphingolipid deregulation, namely the balance between ceramide and sphingosine 1-phosphate, has been implied as a key factor in tumor pathogenesis and apoptosis resistance [ 13, 15].
Supra-physiological oxygen concentrations, as in mechanical ventilation, have been implied as a contributing factor to the development of lung injury; as described by Britt et al., newborn mice exposed to hyperoxia developed lung inflammation linked to cyclooxigenase pathways [ 8].
Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs.
Intriguingly, the combination of a disturbed Ca2+ homeostasis and mitochondrial malfunction, although likely initiated by different mechanisms, has also been implied as an important factor in diabetic neuropathy (reviewed by Verkhratsky and Fernyhough).
Expression of vascular endothelial growth factor (VEGF) has been implied as a hypoxia-induced factor possibly associated to PE, as has been suggested previously [ 8].
Therefore, their interactions are implied as a local process, and histone acetyltransferases may not interact with DNA methylation directly but be correlated via other factors.
NBC News edited a 911 tape of George Zimmerman in a way that implied race as a factor in the Trayvon Martin shooting.
This implied in a factor-12 slowdown.
Previous studies suggest that host factors are crucial determinants of SA carriage [ 50, 52] and the fact that this study could not find any genetic differences between strains colonizing persistent and intermittent carriers, collectively may imply as yet unknown factors (including host, microbiome and environment [ 53]) could primarily be responsible for determining carriage state.
Therefore, abnormal expression of CDC25A was implied as one of the potential oncogenic factors leading to dysregulation of cell cycle control and consequently oncogenic transformation.
