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Dictated by the design of genotyping platforms or the analysis methodologies, the implicit hypotheses of GWAS and their related implications for future research are summarized in this commentary.
To adjust for 15 implicit hypotheses makes it very unlikely that any will pass the statistical test, including the population as a whole, even for substantial associations.
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Therefore, the idea that inserted genes exert no unintended damaging effects is an implicit hypothesis which has become an assumption and is now entrenched as a consensus.
Thus, the implicit hypothesis that students or classes that perform better at t1 also show significantly better development was not confirmed.
(Much of this was apparent 14 years ago [1].) Therefore, the idea that inserted genes exert no unintended damaging effects is an implicit hypothesis which has become an assumption and is now entrenched as a consensus.
It is an implicit hypothesis that perturbation of chromatin and epigenetic signatures may lead to alterations in nuclear structure (or vice versa) and that these perturbations lie at the heart of cancer genesis.
Under such pure-drift divergence models, a strong (and implicit) hypothesis which might often be violated concerns the star shaped phylogeny relating the different populations.
The implicit hypothesis behind both variables is that high-income or highly educated people have better health literacy [ 13, 14].
Greater hands-on experience is associated with increased preparedness, supporting the implicit hypothesis which drives the introduction of practice-based placements – that the availability of more hands-on experience will improve preparedness.
Moreover, the parameterization is done under the (quite frequent) implicit hypothesis that arterial pressure regulation and other CV-related processes only differ quantitatively (e.g. in parameter values) and are otherwise qualitatively similar e.g. in dog, rabbit and man.
An implicit hypothesis of wet-lab, biomedical experiments, illustrated in Figure 5A, is that attributes of the objects or system of study (e.g. mammalian cells) measured in a particular, controlled experimental context (e.g. in vitro) are quantitatively similar to corresponding attributes in particular humans.
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CEO of Professional Science Editing for Scientists @ prosciediting.com