In the present study we focused on the clinical and prognostic implications of the expression of HIF-1α and VEGF in patients with CRC, not only rectal cancer.
Analysis of methylation frequencies within the IG-DMR and Meg3-DMR in GCTSCs compared to MSCs were performed to detect possible implications of epigenetic alterations on the expression of differentially expressed genes and microRNAs that might contribute to GCT pathogenesis.
The acceleration of evolutionary rates in ago-1b and dcr-1b and the existence of positive selection acting on ago-1b suggests the possibility of a neofunctionalization for these copies which might have interesting implications on the regulation of gene expression by miRNAs in aphids.
Although HLA-G expression has been documented in several other cancer sites, i.e. cervical cancer [ 15, 34- 37], melanoma [ 49- 51], breast [ 49, 52- 54], colorectal [ 55- 57], gastric [ 57- 60], esophageal [ 57, 61, 62], lung [ 57, 63, 64], and other cancers [ 49], the implications of HLA-G methylation on the expression of the protein have not been described.
While disputes may remain over whether the role of histone modification in gene expression is causal or concomitant, it has been established that certain combinatorial histone modification patterns have significant implications on gene expression during cellular differentiation.
This finding may have interesting implications on the regulatory mechanisms underlying V2R gene expression that are believed to occur according to a temporal succession in the developing VNO neurons.
To confirm that the observed differential β-catenin expression had functional implications on the Wnt transcriptional program, real-time RT PCR for the detection of Wnt target gene expression was performed.
In this study, we demonstrate that replicative senescence of MSC has functional implications on surface marker expression and differentiation potential and that it evokes consistent changes in the global gene expression and miRNA expression profiles of MSCs from different donors.
These results have implications on the long standing questions concerning the mechanisms of gene expression regulation in trypanosomatids.
Because of this, the effect of environmental changes on the expression of genetic variation in the quantitative traits has important evolutionary implications [ 33].
