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The results of this PK analysis of three different bone formulations show genistein absorption is affected by specific ingredients formulated with the isoflavone which could have clinical implications on efficacy (Table 2; Figure 3).
So, with these data in mind, the bioavailability of genistein depends on specific ingredients and excipients in each formulation which can interfere with absorption and could have clinical implications on efficacy.
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These findings have implications on therapeutic efficacy since monocyte subpopulations have variable expression of scavenger receptors that participate in cholesterol uptake and metabolism.
The main objective was to assess prescription patterns and drug use in pregnancy especially SP; and draw implications on the efficacy of SP for intermittent preventive treatment of malaria in pregnancy (IPTp).
Adherence to instructions regarding consumption in the fasted or fed state cannot be expected and consequently it is important that the effects of food on the bioavailability of moxidectin are thoroughly evaluated to assess potential implications for efficacy and safety.
We considered that the formulation of the placebo may have implications for efficacy.
Changing NNTs over time are an important finding with implications for efficacy comparisons between drugs.
The fact that treatment effectiveness is underestimated by LR or RECIST has important implications on assessing the efficacy of new anticancer drugs or combinations of therapies.
The answers to these questions will have implications on the therapeutic efficacy of primary tumor resection and additional measures that may need to be taken in order to suppress metastatic outgrowth.
Such findings serve to emphasise that very subtle alterations in amino acid residues can have major implications on drug binding efficacy and highlight the importance of understanding the structural basis of drug binding, which is not always apparent from analysis of DNA sequences.
Our results also have implications on the efficiency and efficacy in the regeneration of other epithelial organs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com