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They further showed that CARD-mediated RING regulation had implications on cell proliferation and migration.
Interestingly, GH-transgenic mice lacking one copy of SOCS2 show a high incidence in aberrant lesions in the colon indicating that small variations of SOCS2 expression levels can have profound implications on cell proliferation and eventually tumor growth [ 47].
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We also analyzed cell migration in the presence of the proliferation inhibitor PD-98059 to rule out the potential implication of cell proliferation in this assay.
This study demonstrates the resolution of intratumor heterogeneity for profiling studies based on cell proliferation, a defining feature of cancers, with implications for treatment design.
Increasing IGFBP-3 levels in breast tumours may indicate adverse prognostic cancers, with contradictory implications on patient outcomes[ B24, 25] to reflect the complexity of IGFBP-3 effects on cell proliferation[ B27, 28, 30].
Roughness has important effect on cell proliferation and differentiation.
The controls had no effect on cell proliferation.
Fig. 1 Effects of hyperoxia on cell proliferation.
Additionally, combination of these surface modifications has an additive effect on cell proliferation.
First, we evaluated the effect of fucoidan on cell proliferation.
The effect of miR-638 on cell proliferation was measured by counting kit-8 assay.
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