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We agree with the reviewers that the implications of virus segmentation could be discussed more thoroughly and we have now added some additional text on this matter.
Highly specific and sensitive assays to detect PARV4 will facilitate further analysis of the role of this novel virus in human disease and the implications of virus transmission by contaminated blood and blood products.
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Although the possible epidemiological and pathogenetic roles of these amino acids substitutions have not yet been fully investigated, these findings raise concerns for the possible human health implications of viruses with these genetic characteristics.
Based on these observations, the implications of influenza virus infections, including those caused by HPAI H5N1 viruses, for bird health and ecology and virus epidemiology may require re-evaluation.
While the implications of Zika virus infection for unborn babies have yet to be fully unravelled, the virus has already been declared to be a cause of the birth defect microcephaly.
The medical implications of this virus for humans and animals in this region have not been determined, although the virus has been associated with human infection and illness in eastern Europe and West Africa (21 – 21 ).
Evidence of reverse zoonotic transmission by fomites underscores the substantial animal and human health implications of this virus.
Insights into reassortment and rates of coinfection have important implications for virus population structure in nature, which remains largely unexplored [ 31- 33].
The clinical implication of measuring virus load in upper respiratory tract specimens for MERS-CoV is not clear because the virus load probably reflects virus replication in the nasopharyngeal epithelial cells.
This unique viral genome carries implications for theories of virus emergence and evolution, as no mechanism for interviral RNA-DNA recombination has yet been identified, and only scant evidence exists that genetic exchange occurs between such distinct virus lineages.
The implications for virus biology and the design of thermostable vaccines are discussed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com