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While the structural implications of this modification on these interactions is understood to some extent for p53 [ 13, 59, 60, 62, 63] little is known about p63 and p73.
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Consequently, our finding that the pattern and level of glutathiolation of nuclear proteins change during the cell cycle [24] and with the depletion of nuclear GSH could contribute to the possible implication of this modification in the control of chromatin structure dynamics (for review see [62]).
Further studies are indicated to evaluate the implications of this potential modification of keratoplasty surgery.
The importance of lysine acetylation is well appreciated in the context of nuclear histone modifications (Strahl and Allis, 2000), but the regulatory implications of the modification extend beyond gene regulation.
Regarding the controller structure, the main implication of introducing this modification lies in the fact that it states the possibility of implementing a control law for a general class of models for this kind of motors.
The functional implications of these modifications are not clearly defined yet; however, an increasing number of investigations suggest two possible roles.
Intense investigation into the role of post-translational modifications, specifically phosphorylation and acetylation, has now begun, driven by the potential implications of these modifications in Alzheimer's disease (AD) and other tauopathies [ 4, 11, 16, 18, 19].
The implication of this change is exciting.
We can use equation 10 with one small change to describe the implications of effect modification of the risk difference by group.
This allows us to quantify the population implications of experimental modifications of landscape configuration and composition.
Selective pharmacological inhibition of extracellular TG2 should be useful in exploring the mechanistic implications of TG2-catalyzed modification of dietary gluten, a phenomenon of considerable relevance in Celiac Sprue.
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