Sentence examples for implications of these mutations from inspiring English sources

The implications of these mutations are discussed using a structural model of the XPD protein.

To study the structural and functional implications of these mutations on RING2-REP domain of Parkin, we studied the solvent accessibility (SASA/RSA), hydrophobicity, intra-molecular hydrogen bonding profile and domain analysis by various computational tools.

Further investigation is warranted as to the functional implications of these mutations in carcinogenesis.

The prognostic implications of these mutations were highly subgroup-specific.

Here, we have summarized the PSEN2 mutations and the potential implications of these mutations in dementia-associated disorders.

There is also limited knowledge of the implications of these mutations with regard to development of severe hemolytic disease in the United States population.

We discuss here known mechanisms of oncogenesis and the clinical implication of these mutations.

As functional consequences on RAS protein could be different of codons 12 and 13 mutations, the clinical implication of these mutations remained unclear until recently [ 6, 18].

A recent breakthrough in our understanding of the pathogenesis of NB is the identification of activating point mutations in the tyrosine kinase domain of the ALK gene as the main cause of familial NB, and implication of these mutations in a substantial fraction of sporadic NB tumors [ 59- 63].

As TERT mutations are predominantly observed in non-infant medulloblastomas, we evaluated the prognostic implications of these promoter mutations across all four medulloblastoma subgroups in an age-dependent manner.

We therefore investigated the potential biological implications of these convergent mutations.